The Hsp105 (8T1) Monoclonal Antibody from Bioss Inc. is a Rabbit Monoclonal antibody to HSPH1. This antibody recognizes Human, Mouse, and Rat antigen. The Hsp105 (8T1) Monoclonal Antibody has been validated for the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity)